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National Institutes of Health

NIMH Pages about Schizophrenia

Learn more about Schizophrenia…

Clinical Trials Page

Find current studies on Schizophrenia…

Publications

Schizophrenia
A detailed booklet that describes symptoms, causes, and treatments, with information on getting help and coping.
Date: 2009
También disponible en Español
Schizophrenia (Easy-to-Read)
An easy-to-read booklet on Schizophrenia that explains what it is, when it starts and how to get help.
Date: 2009
Looking at My Genes: What Can They Tell Me?
A fact sheet containing frequently asked questions about genome scans and genetic testing.
Date: 2008

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Science News

High-Tech Robots’ Efforts Bear Fruit Thanks to NIH Roadmap
October 08, 2009 • Science Update
Researchers recently announced discovery of a new class of molecules that holds promise for blocking the clumps of protein that clog the brain in Alzheimer’s disease. The new findings are the latest made possible by the NIH Roadmap Molecular Libraries initiative, which employs high-tech robots and molecular genetics to speedily screen molecules for their biological effects. The discovery required testing nearly 300,000 compounds – a task thought insurmountable just a decade ago.
Atlas Will Reveal When and Where Genes Turn On in the Brain
October 06, 2009 • Science Update
When and where in the brain a gene turns on holds clues to its possible role in disease. For example, a recent study found that forms of a gene associated with schizophrenia are over-expressed in the fetal brain, adding to evidence implicating this critical developmental period.
First Direct Evidence: Instability is the Normal State of the Brain’s Cortex
September 21, 2009 • Science Update
Even when we’re not doing much of anything, our brain’s cortex, or outer mantle, is bustling with activity. In fact, scientists for the first time have detected “avalanches” of cortex activity in awake monkeys at rest.
Schizophrenia Linked to Over-expression of Gene in Fetal Brain
August 28, 2009 • Science Update
A gene called DISC1, (for “disrupted in schizophrenia”) has been a leading contender among possible genetic causes since it was implicated in schizophrenia in a large Scottish clan two decades ago. The DISC1 gene codes for a protein important for brain development, as well as for mood and memory – functions that are disturbed in schizophrenia. However, until now there have been few clues as to how DISC1 might increase risk for the chronic mental disorder.
Major NIMH Research Project to Test Approaches to Altering the Course of Schizophrenia
July 21, 2009 • Press Release
The National Institute of Mental Health (NIMH) is launching a large-scale research project to explore whether using early and aggressive treatment, individually targeted and integrating a variety of different therapeutic approaches, will reduce the symptoms and prevent the gradual deterioration of functioning that is characteristic of chronic schizophrenia.

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Meeting Summaries

Child and Adolescent Onset Schizophrenia: Research Challenges and Opportunities
June 25, 2007 – June 26, 2007
Bethesda, Maryland
In June 2007, NIMH and the NIH ORD convened a meeting for brainstorming and discussion between basic, translational, and clinical investigators to review the current knowledge on causes, neurobiology, developmental trajectory, and treatment of child- and adolescent-onset schizophrenia.
International Society for CNS Clinical Trials and Methodology (ISCTM) Meeting
January 20, 2006
Washington, DC
In February 2006, the ISCTM held this meeting by satellite on the NIMH initiative regarding treatment development for negative symptoms of schizophrenia.

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