Science News about Clinical Research and Trials
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Science News about Clinical Research and Trials
- Parent Training Complements Medication for Treating Behavioral Problems in Children with Pervasive Developmental Disorders
- November 20, 2009 • Press Release
Treatment that includes medication plus a structured training program for parents reduces serious behavioral problems in children with autism and related conditions, according to a study funded by the National Institute of Mental Health (NIMH). The study, which was part of the NIMH Research Units on Pediatric Psychopharmacology (RUPP) Autism Network, was published in the December 2009 issue of the Journal of the American Academy of Child and Adolescent Psychiatry. - Long-term Depression Treatment Leads to Sustained Recovery for Most Teens
- November 18, 2009 • Science Update
Long-term treatment of adolescents with major depression is associated with continuous and persistent improvement of depression symptoms in most cases, according to the most recent analysis of follow-up data from the NIMH-funded Treatment of Adolescents with Depression Study (TADS). The report, along with a commentary compiling the take-home messages of the study, was published in the October 2009 issue of the American Journal of Psychiatry. - Clinical Tests Begin on Medication to Correct Fragile X Defect
- November 02, 2009 • Press Release
NIH-supported scientists at Seaside Therapeutics in Cambridge, Mass., are beginning a clinical trial of a potential medication designed to correct a central neurochemical defect underlying Fragile X syndrome, the most common inherited cause of intellectual disability. There has to date been no medication that could alter the disorder’s neurologic abnormalities. The study will evaluate safety, tolerability, and optimal dosage in healthy volunteers. - Telephone-based Depression Treatment Program Effective While Cost Efficient
- October 16, 2009 • Science Update
Patients who receive structured, telephone-based support to manage their depression gain significant benefits with only moderate increases in health care costs compared to those who receive usual care, according to an NIMH-funded analysis published in the October 2009 issue of the Archives of General Psychiatry. - New Approach to Reducing Suicide Attempts Among Depressed Teens
- September 29, 2009 • Science Update
A novel treatment approach that includes medication plus a newly developed type of psychotherapy that targets suicidal thinking and behavior shows promise in treating depressed adolescents who had recently attempted suicide, according to a treatment development and pilot study funded by the National Institute of Mental Health (NIMH). The study, described in three articles, was published in the October 2009 issue of the Journal of the American Academy of Child and Adolescent Psychiatry. - Combination Treatment for Psychotic Depression Holds Promise
- August 07, 2009 • Science Update
A combination of an atypical antipsychotic medication and an antidepressant known as a selective serotonin reuptake inhibitor (SSRI) may be more effective in treating psychotic depression than an atypical antipsychotic alone, according to results from an NIMH-funded clinical study. - Searching for Risk Factors of Suicidal Events During Antidepressant Treatment
- May 29, 2009 • Science Update
A new set of analyses of the NIMH-funded Treatment for Adolescents with Depression Study (TADS) were conducted to better understand what may predict the development of suicidal events during treatment. The analyses, which were published in the May 2009 issue of the Journal of Clinical Psychiatry, showed that youths with suicidal thoughts and more severe depression prior to treatment were at higher risk for suicidal events while undergoing treatment. - HIV Prevention Program Gets a Boost From NIMH Recovery Act Funds
- May 26, 2009 • Press Release
Developing interventions to reduce the spread of HIV and other sexually transmitted infections among heterosexual men, couples and ethnically diverse populations continues to be complex and challenging. To help address this issue, NIMH awarded a two-year grant to David Pérez-Jiménez, Ph.D., at the University of Puerto Rico, to support the adaptation and assessment of an HIV and other sexually transmitted infection intervention designed for young, heterosexual Latino couples. This grant will use funds allocated to NIMH through the American Recovery and Reinvestment Act to promote economic recovery and spur advances in science and health. - Short-term Intensive Treatment Not Likely to Improve Long-term Outcomes for Children with ADHD
- March 26, 2009 • Science Update
Short-term Intensive Treatment Not Likely to Improve Long-term Outcomes for Children with ADHD - Brain Awareness Week Teaches Kids How Their Brains Work
- March 17, 2009 • Press Release
The 10th annual Brain Awareness Week (BAW), a science and health education fair held in various locations across the United States, teaches fifth through eighth grade students about the brain. In Washington, D.C., it will take place March 16-20, 2009, at the National Museum of Health and Medicine at Walter Reed Army Medical Center. Several institutes from the National Institutes of Health will provide interactive exhibits and lectures focusing on brain health and neuroscience on March 18th and 19th. - Adolescents with Depression Not Harmed in Studies Using Placebo
- January 15, 2009 • Science Update
Teens with depression who initially are randomly assigned to placebo treatment (inactive pill) during a trial are no more likely to experience harm or have a diminished response to subsequent active treatments than teens who are initially randomized to active treatment, according to an analysis of data from the NIMH-funded Treatment for Adolescents with Depression Study (TADS). - Intervention Helps Reduce Risky Sexual Behavior Among Homeless HIV-positive Adults
- December 16, 2008 • Science Update
An NIMH-funded program already shown to reduce risky sexual and substance abuse behavior among HIV-infected adults also appears to be effective in improving the lives of HIV-infected homeless or near-homeless adults, according to a new report. - Depression Relapse Less Likely Among Teens Who Receive CBT After Medication Therapy
- December 05, 2008 • Science Update
Adolescents with major depression who received cognitive behavioral therapy (CBT) after responding to an antidepressant were less likely to experience a relapse or recurrence of symptoms compared to teens who did not receive CBT, according to a small, NIMH-funded pilot study published in the December 2008 issue of the Journal of the American Academy of Child and Adolescent Psychiatry. - NIMH, U.S. Army Sign MOA to Conduct Groundbreaking Suicide Research
- November 12, 2008 • Science Update
NIMH and the U.S. Army have entered into a memorandum of agreement (MOA) to conduct research that will help the Army reduce the rate of suicides. - Study Identifies Three Effective Treatments for Childhood Anxiety Disorders
- October 30, 2008 • Press Release
Treatment that combines a certain type of psychotherapy with an antidepressant medication is most likely to help children with anxiety disorders, but each of the treatments alone is also effective. - Certain Antipsychotic Medications May Increase Risk for Heart Disease
- October 16, 2008 • Science Update
Certain atypical antipsychotic medications may raise the risk for heart disease in people with schizophrenia, according to an analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. - New Study to Evaluate Ways to Control Metabolic Side Effects of Antipsychotics
- October 01, 2008 • Science Update
A new NIMH-funded grant will examine ways to control the metabolic side effects associated with the use of the newer atypical antipsychotic medications in children with schizophrenia or bipolar disorder. - Newer Antipsychotics No Better Than Older Drug in Treating Child and Adolescent Schizophrenia
- September 15, 2008 • Press Release
Two newer atypical antipsychotic medications were no more effective than an older conventional antipsychotic in treating child and adolescent schizophrenia and may lead to more metabolic side effects, according to a new study funded by the National Institutes of Health’s National Institute of Mental Health (NIMH). - Family-Focused Therapy Effective in Treating Depressive Episodes of Bipolar Youth
- September 01, 2008 • Science Update
Adolescents with bipolar disorder who received a nine-month course of family-focused therapy (FFT) recovered more quickly from depressive episodes and stayed free of depression for longer periods than a control group, according to an NIMH-funded study published September 2008 in the Archives of General Psychiatry. - New Research to Refine Approaches in Psychotherapy
- August 29, 2008 • Science Update
Psychotherapy is a crucial part of treatment for many mental disorders, but it can be difficult to identify the right approach for an individual. - Antipsychotic Does Not Harm—and May Improve—Cognitive Skills in Children with Autism
- August 27, 2008 • Science Update
The atypical antipsychotic medication risperidone (Risperdal) does not negatively affect cognitive skills of children with autism, and may lead to improvements, according to an NIMH-funded study published recently in the Journal of Child and Adolescent Psychopharmacology. - Health Risks Associated with Certain Antipsychotics Warrant Extra Monitoring
- July 24, 2008 • Science Update
Some atypical antipsychotics may be more likely than others to cause metabolic and cardiovascular side effects, according to recent analyses using data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). - Age-related Decline of ADHD Symptoms Disrupted by Middle School
- July 21, 2008 • Science Update
Although symptoms of attention deficit/hyperactivity (ADHD) can last into adulthood, typically they decline as a child gets older. - Newer Antipsychotics No Better Than Older Medications in Reducing Schizophrenia-related Violence
- July 11, 2008 • Science Update
Antipsychotic medications can reduce the risk of violence among people with schizophrenia, but the newer atypical antipsychotics are no more effective in doing so than older medications, according to a recent analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). - Violence in Schizophrenia Patients More Likely Among Those with Childhood Conduct Problems
- July 02, 2008 • Press Release
Some people with schizophrenia who become violent may do so for reasons unrelated to their current illness, according to a new study analyzing data from the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE). - Antipsychotic Medications May Ease Some Alzheimer’s Symptoms, Not Others
- June 23, 2008 • Science Update
Antipsychotic medications may lessen symptoms like hostility and aggression in patients with Alzheimer’s disease, but do not appear to lessen other symptoms or improve quality of life, according to a recent analysis of data from the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness Alzheimer’s Disease (CATIE-AD) study. - New Grant Aims to Overcome Obesity in People with Serious Mental Illness
- June 20, 2008 • Science Update
A new grant funded by NIMH will test the effectiveness of a promising intervention designed to help people with serious mental illness (SMI) who are overweight or obese lose weight and keep it off. - HIV-positive Survivors of Sexual Abuse Who Receive Coping Intervention Less Likely to Engage in Unprotected Sex
- May 23, 2008 • Science Update
HIV-positive people who have experienced childhood sexual abuse are less likely to engage in risky sexual behavior if they receive a group intervention designed to help them cope with their traumatic history, according to an NIMH-funded study published April 1, 2008, in the Journal of Acquired Immune Deficiency Syndrome. - Medication-only Therapy and Combination Therapy Both Cost Effective for Treating Teens with Depression
- May 12, 2008 • Science Update
Treating depressed teenagers with either the antidepressant fluoxetine (Prozac) or a combination of fluoxetine and psychotherapy can be cost effective, according to a recent economic analysis of the NIMH-funded Treatment for Adolescents with Depression Study (TADS). The study was published online ahead of print April 15, 2008, in the American Journal of Psychiatry. - Study launched to test possible preventive treatment for schizophrenia in high risk youth
- May 01, 2008 • Science Update
NIMH has recently awarded a grant to study whether an intensive computerized training program can help prevent those at high risk of developing schizophrenia from having a first psychotic episode and improve adaptive functioning. The program is based on principles of brain development and resilience and an understanding of the processes that go awry in schizophrenia. - Maintenance Treatment Crucial for Teens’ Recovery from Depression
- April 08, 2008 • Science Update
Long-term maintenance treatment is likely to sustain improvement and prevent recurrence among adolescents with major depression, according to an NIMH-funded study published in the April 2008 issue of the Archives of General Psychiatry. - Group Therapy Program Offers Meaningful Gains for People with Borderline Personality Disorder
- February 26, 2008 • Science Update
A 20-week group therapy program focusing on cognitive behavioral and skills training, when used in conjunction with usual care, helped reduce symptoms of borderline personality disorder and improve overall functioning, reported NIMH-funded researchers. - Teens with Treatment-resistant Depression More Likely to Get Better with Switch to Combination Therapy
- February 26, 2008 • Press Release
Teens with difficult-to-treat depression who do not respond to a first antidepressant medication are more likely to get well if they switch to another antidepressant medication and add psychotherapy rather than just switching to another antidepressant, according to a large, multi-site trial funded by the National Institutes of Health’s National Institute of Mental Health (NIMH). The results of the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial were published February 27, 2008, in the Journal of the American Medical Association (JAMA). - Co-occurring Anxiety Complicates Treatment Response for Those with Major Depression
- February 25, 2008 • Science Update
People with major depression accompanied by high levels of anxiety are significantly less likely to benefit from antidepressant medication than those without anxiety, according to a study based on data from the NIMH-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. The study was published online ahead of print in January 2008, in the American Journal of Psychiatry. - Genetic Variation May Influence Response to Depression Treatment
- February 20, 2008 • Science Update
Variations in a gene known as TREK1 may explain some forms of treatment-resistant major depression, according to a new study analyzing genetic data from the NIMH-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. The study was published online February 20, 2008, in Neuropsychopharmacology. - Team Care for Depressed Older Adults Cuts Overall Medical Costs
- February 14, 2008 • Science Update
A team approach to depression treatment for older adults, already shown to be effective, is also less expensive than usual care, according to an NIMH-funded study published February 2008 in the American Journal of Managed Care. - Family-Centered Intervention Effectively Reduces Risky Behavior Among Hispanic Youth
- December 20, 2007 • Science Update
Science Update December 20, 2007 Family-centered Intervention Effectively Reduces Risky Behavior Among Hispanic Youth A family-centered program that improves parent-child dynamics and family functioning is more effective at discouraging Hispanic youth from engaging in risky behavior than programs that target specific behaviors, according to a study published in the December 2007 issue of the Journal of Consulting and Clinical Psychology. - Behavioral Therapy Effectively Treats Children with Social Phobia
- December 17, 2007 • Science Update
A behavioral therapy designed to treat children diagnosed with social phobia helped them overcome more of their symptoms than the antidepressant fluoxetine (Prozac). - Behavioral Program May Stabilize Stress Hormone Patterns in Foster Children
- November 30, 2007 • Science Update
An intervention designed to enhance family interaction and improve foster parenting skills may benefit young foster children who had experienced extreme neglect or maltreatment in early life. - Depressed Adolescents Respond Best to Combination Treatment
- October 01, 2007 • Press Release
A combination of psychotherapy and antidepressant medication appears to be the most effective treatment for adolescents with major depressive disorder—more than medication alone or psychotherapy alone, according to results from a major clinical trial funded by the National Institutes of Health’s National Institute of Mental Health (NIMH). - Family Involvement and Focused Intervention May be Key to Helping Teens with Bulimia
- September 17, 2007 • Science Update
Family-based treatment for adolescent bulimia nervosa (FBT-BN) is more effective than an individual-based therapy called supportive psychotherapy (SPT) in helping teens overcome bulimia according to an NIMH-funded study. - Studies Refine Understanding of Treatments for Bipolar Disorder
- September 01, 2007 • Science Update
Two new studies provide additional details on best practices for treating people with bipolar disorder, a sometimes debilitating illness marked by severe mood swings between depression and mania. - Bipolar Youth Show Distinct Pattern of Brain Development
- August 28, 2007 • Science Update
The first picturess of the brain changing before-and-after the onset of pediatric bipolar disorder reveal a distinct pattern of development, when compared to that seen in healthy youth or in childhood onset schizophrenia. - Suspect Schizophrenia Genes Act Together to Thwart Working Memory
- August 28, 2007 • Science Update
Two gene variants implicated in schizophrenia interact to degrade the brain's ability to process information, NIMH researchers have discovered. - Unpleasant Words Trigger Strong Startle Response in People with Borderline Personality Disorder
- August 22, 2007 • Science Update
Adults with borderline personality disorder (BPD) showed excessive emotional reactions when looking at words with unpleasant meanings compared to healthy people during an emotionally stimulating task, according to NIMH-funded researchers - Behavioral Interventions Effective for Preschoolers with ADHD
- August 15, 2007 • Science Update
Two types of early interventions designed to reduce symptoms of attention deficit-hyperactivity disorder (ADHD) in preschoolers may be effective alternatives or additions to medication treatment, according to a recent NIMH-funded study. - Half of Children With Autism May be Diagnosable Soon After Their First Birthday
- August 10, 2007 • Science Update
About half of children with autism spectrum disorders (ASD) can be diagnosed soon after their first birthday; others with the disorder may appear to develop normally until that age and then falter or regress during their second year, NIMH-funded researchers have discovered. - Parents' Diagnoses Help to Distinguish Childhood Bipolar Disorder from Severe Mood Dysregulation
- August 06, 2007 • Science Update
The parents of children who have bipolar disorder are more likely to have bipolar disorder themselves than the parents of children who have severe mood dysregulation (SMD). - Success or Failure of Antidepressant Citalopram Predicted by Gene Variation
- August 01, 2007 • Press Release
A variation in a gene called GRIK4 appears to make people with depression more likely to respond to the medication citalopram (Celexa) than are people without the variation, a study by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, has found. - Faster-Acting Antidepressants Closer to Becoming a Reality
- July 24, 2007 • Press Release
A new study has revealed more about how the medication ketamine, when used experimentally for depression, relieves symptoms of the disorder in hours instead of the weeks or months it takes for current antidepressants to work. - Improvement Following ADHD Treatment Sustained in Most Children
- July 20, 2007 • Press Release
Most children treated in a variety of ways for attention deficit hyperactivity disorder (ADHD) showed sustained improvement after three years in a major follow-up study funded by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH). - Gene Variants Linked to Suicidal Thoughts in Some Men Starting Antidepressant Treatment
- June 07, 2007 • Science Update
Some men who experience suicidal thoughts and behaviors after they first start taking antidepressant medications may be genetically predisposed to do so, according to the latest results from the NIMH-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study - Antipsychotic Medications for Schizophrenia on Equal Footing in Improving Patients’ Thinking Skills
- June 04, 2007 • Science Update
Patients with schizophrenia taking antipsychotic medications experience a small improvement in thinking and reasoning skills (neurocognition), but no one medication appears to be better than the others in improving these skills during the first two crucial months of treatment, according to the latest results from the NIMH-funded Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE). - In Second Try to Treat Depression, Cognitive Therapy Generally As Effective As Medication
- May 01, 2007 • Science Update
Switching to or adding cognitive therapy (CT) after a first unsuccessful attempt at treating depression with an antidepressant medication is generally as effective as switching to or adding another medication, but remission may take longer to achieve - Intensive Psychotherapy More Effective Than Brief Therapy for Treating Bipolar Depression
- April 02, 2007 • Press Release
Patients taking medications to treat bipolar disorder are more likely to get well faster and stay well if they receive intensive psychotherapy, according to results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), funded by the National Institutes of Health’s (NIH) National Institute of Mental Health (NIMH). - Study Sheds Light on Medication Treatment Options for Bipolar Disorder
- March 28, 2007 • Press Release
For depressed people with bipolar disorder who are taking a mood stabilizer, adding an antidepressant medication is no more effective than a placebo (sugar pill), according to results published online on March 28, 2007 in the New England Journal of Medicine. - HIV Treatment May Help Reduce Severity of Mental Impairment in Children with HIV Infection
- March 07, 2007 • Science Update
During the first few years of life, children born with HIV infection are most susceptible to central nervous system (CNS) disease, and can develop impaired cognitive, language, motor and behavioral functioning. However, NIH-funded researchers have found that among children with HIV infection, treatment with a protease inhibitor (PI)- based highly active antiretroviral therapy (HAART) helped protect against cognitive and motor difficulties compared to a control group of age-matched children who were born to HIV-infected mothers but who did not contract the virus themselves (e.g., HIV-exposed). - New Details in Schizophrenia Treatment Trial Emerge
- March 01, 2007 • Press Release
Two new studies from the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) provide more insights into comparing treatment options, and to what extent antipsychotic medications help people with schizophrenia learn social, interpersonal and community living skills. - Landmark Council Session Spotlights “Real World” Trials
- December 21, 2006 • Science Update
Principal investigators of NIMH's four large-scale clinical trials presented study results and their implications at the National Advisory Mental Health Council meeting on September 15, 2006. - Older Medication May Be More Cost-Effective for Some Patients with Schizophrenia
- December 01, 2006 • Press Release
A new study analyzing the economic implications of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) concludes that the older (first generation) antipsychotic medication perphenazine was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment, suggesting that older antipsychotics still have a role in treating schizophrenia. - New NIMH Research Strives to Understand How Antidepressants May Be Associated with Suicidal Thoughts and Actions
- November 13, 2006 • Science Update
The National Institute of Mental Health (NIMH), part of the National Institutes of Health, is funding five new research projects that will shed light on antidepressant medications, notably selective serotonin reuptake inhibitors (SSRIs), and their association with suicidal thoughts and actions. - Odds of Beating Depression Diminish as Additional Treatment Strategies are Needed
- November 01, 2006 • Science Update
An overall assessment of the nation's largest real-world study of treatment-resistant depression suggests that a patient with persistent depression can get well after trying several treatment strategies, but his or her odds of beating the depression diminish as additional treatment strategies are needed. - Antipsychotic Medications Used to Treat Alzheimer’s Patients Found Lacking
- October 11, 2006 • Press Release
Commonly prescribed antipsychotic medications used to treat Alzheimer’s patients with delusions, aggression, hallucinations, and other similar symptoms can benefit some patients, but they appear to be no more effective than a placebo when adverse side effects are considered, according to the first phase of a large-scale clinical trial funded by NIMH. - New Schizophrenia Trial: Does Method of Administering Medication Make a Difference?
- September 05, 2006 • Science Update
A new clinical trial is testing whether an injection of a long-lasting antipsychotic medication every two weeks results in better adherence to treatment and better outcomes among people with schizophrenia than do oral medications taken daily. - Subsequent Treatment Strategies for Persistent Depression Yield Modest Results
- September 01, 2006 • Science Update
Patients with treatment-resistant depression had a modest chance of becoming symptom-free when they tried different treatment strategies after two or three failed treatments, according to results from the nation's largest real-world study of depression. - Brain Changes Mirror Symptoms in ADHD
- July 19, 2006 • Science Update
The severity of attention deficit hyperactivity disorder (ADHD) symptoms in youth appears to be reflected in their brain structure, recent NIMH-supported brain imaging studies are finding. - New Factors Identified for Predicting Violence in Schizophrenia
- July 18, 2006 • Science Update
A study of adults with schizophrenia showed that symptoms of losing contact with reality, such as delusions and hallucinations, increased the odds of serious violence nearly threefold. - Targeted Therapy Halves Suicide Attempts in Borderline Personality Disorder
- July 03, 2006 • Science Update
Dialectical Behavior Therapy (DBT) reduced suicide attempts by half compared with other types of psychotherapy available in the community in patients with borderline personality disorder, an NIMH-funded study has found. - Switching to a Third Antidepressant Medication May Prove Helpful to Some with Treatment-Resistant Depression
- July 01, 2006 • Science Update
The next wave of results from the nation's largest real-world study of treatment-resistant depressionshows that patients had a moderate chance of becoming symptom-free when they switched to a third antidepressant medication, following two previously unsuccessful medication attempts. - Antidepressant Does Not Reduce Risk Of Relapse Among Patients With Anorexia Nervosa
- June 14, 2006 • Science Update
An NIMH-funded study has concluded that the antidepressant medication fluoxetine (Prozac) is no more effective than placebo in preventing relapse among patients with anorexia nervosa who had achieved a healthy weight during inpatient or day-program treatment. - Intermittent Explosive Disorder Affects up to 16 Million Americans
- June 05, 2006 • Press Release
A little-known mental disorder marked by episodes of unwarranted anger is more common than previously thought, a study funded by NIMH has found. - Depression Rates Are Lower in Children Whose Mothers Are Successfully Treated
- May 09, 2006 • Science Update
When women treated for depression become symptom-free, their children are less likely to be diagnosed with depression, according to a study published in the March 22/29 issue of the Journal of the American Medical Association. - Studies Offer New Information About Treatment Choices for Schizophrenia — Phase 2 Results
- April 01, 2006 • Science Update
A national clinical trial comparing clozapine with other new-generation antipsychotic medications for the treatment of chronic schizophrenia has shown that people who switched to clozapine from their first medication because it failed to manage symptoms adequately were twice as likely to continue treatment as patients who switched to other antipsychotic medications. - New Strategies Help Depressed Patients Become Symptom-Free
- March 23, 2006 • Press Release
Results of the nation’s largest depression study show that one in three depressed patients who previously did not achieve remission using an antidepressant became symptom-free with the help of an additional medication and one in four achieved remission after switching to a different antidepressant. - Gene Influences Antidepressant Response
- March 15, 2006 • Press Release
Whether depressed patients will respond to an antidepressant depends, in part, on which version of a gene they inherit, a study led by scientists at NIH has discovered. Having two copies of one version of a gene that codes for a component of the brain’s mood―regulating system increased the odds of a favorable response to an antidepressant by up to 18 percent, compared to having two copies of the other, more common version. - Early Findings from Largest NIMH-Funded Research Program on Bipolar Disorder Begin to Build Evidence-Base on Best Treatment Options
- February 01, 2006 • Science Update
Findings from an NIMH research program on bipolar disorder provide much needed long-term data on the chronic, recurrent course of the disorder, and begin the work of building an evidence-base on the best treatments for those with the disorder. - Initial Results Help Clinicians Identify Patients with Treatment-Resistant Depression
- January 06, 2006 • Press Release
Initial results of the nation’s largest clinical trial for depression have helped clinicians to track “real world” patients who became symptom-free and to identify those who were resistant to the initial treatment. - NIMH Study To Guide Treatment Choices for Schizophrenia (Phase 1 Results)
- September 19, 2005 • Press Release
A large study funded by NIH's National Institute of Mental Health (NIMH) provides, for the first time, detailed information comparing the effectiveness and side effects of five medications — both new and older medications — that are currently used to treat people with schizophrenia. - Combination Treatment Most Effective in Adolescents with Depression
- August 17, 2004 • Press Release
A clinical trial of 439 adolescents with major depression has found a combination of medication and psychotherapy to be the most effective treatment. - Gene More Than Doubles Risk Of Depression Following Life Stresses
- July 17, 2003 • Press Release
Among people who suffered multiple stressful life events over 5 years, 43 percent with one version of a gene developed depression, compared to only 17 percent with another version of the gene, say researchers funded, in part, by the National Institute of Mental Health (NIMH). - NIH Awards Grants for Six New Autism Research Centers
- May 13, 2003 • Press Release
The National Institutes of Health (NIH) has awarded grants to support six new research centers of a major network focusing on the biomedical and behavioral aspects of autism. - Gene Enhances Prefrontal Function at a Price
- May 07, 2003 • Press Release
Studies of a gene that affects how efficiently the brain’s frontal lobes process information are revealing some untidy consequences of a tiny variation in its molecular structure and how it may increase susceptibility to schizophrenia. - Study Boosts Confidence in Potential Screening Tool for Alzheimer's Disease
- April 22, 2003 • Press Release
A major study has confirmed the value of potential markers for identifying people with Alzheimer's disease. - Treatment for Minor Depression
- March 21, 2003 • Press Release
In a new approach to research on minor depression, the National Institutes of Health (NIH) has launched a four-year study to determine the safety and effectiveness of St. John's wort, a common herbal supplement, and citalopram, a standard antidepressant, compared to placebo. - Human Gene Affects Memory
- January 23, 2003 • Press Release
NIH scientists have shown that a common gene variant influences memory for events in humans by altering a growth factor in the brain's memory hub. - NIH Awards Grants for Two New Autism Research Centers
- September 18, 2002 • Press Release
The National Institutes of Health (NIH) announced grants totaling $19 million to support the first two research centers of a major network of facilities to focus on the biomedical and behavioral aspects of autism. - Placebo, Antidepressant May Lift Depression Via Common Mechanism
- May 01, 2002 • Press Release
Whether it's a widely prescribed medication or a placebo, a successful treatment for depression must trigger a common pattern of brain activity changes, suggests a team of researchers funded by the National Institute of Mental Health.
