Science News
about Clinical Research And Trials
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- In Second Try to Treat Depression, Cognitive Therapy Generally As Effective As Medication
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May 1, 2007
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Science Update
Switching to or adding cognitive therapy (CT) after a first unsuccessful attempt at treating depression with an antidepressant medication is generally as effective as switching to or adding another medication, but remission may take longer to achieve.
- Intensive Psychotherapy More Effective Than Brief Therapy for Treating Bipolar Depression
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April 2, 2007
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Press Release
Patients taking medications to treat bipolar disorder are more likely to get well faster and stay well if they receive intensive psychotherapy, according to results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), funded by NIMH.
- Study Sheds Light on Medication Treatment Options for Bipolar Disorder
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March 28, 2007
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Press Release
For depressed people with bipolar disorder who are taking a mood stabilizer, adding an antidepressant medication is no more effective than a placebo (sugar pill), according to results published online on March 28, 2007 in the New England Journal of Medicine.
- HIV Treatment May Help Reduce Severity of Mental Impairment in Children with HIV Infection
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March 7, 2007
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Science Update
During the first few years of life, children born with HIV infection are most susceptible to central nervous system (CNS) disease, and can develop impaired cognitive, language, motor and behavioral functioning.
- New Details in Schizophrenia Treatment Trial Emerge
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March 1, 2007
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Press Release
Two new studies from the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) provide more insights into comparing treatment options, and to what extent antipsychotic medications help people with schizophrenia learn social, interpersonal and community living skills.
- Landmark Council Session Spotlights “Real World” Trials
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December 21, 2006
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Science Update
Principal investigators of NIMH's four large-scale clinical trials presented study results and their implications at the National Advisory Mental Health Council meeting on September 15, 2006.
- Older Medication May Be More Cost-Effective for Some Patients with Schizophrenia
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December 1, 2006
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Press Release
A new study analyzing the economic implications of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) concludes that the older (first generation) antipsychotic medication perphenazine was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment, suggesting that older antipsychotics still have a role in treating schizophrenia.
- New NIMH Research Strives to Understand How Antidepressants May Be Associated with Suicidal Thoughts and Actions
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November 13, 2006
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Science Update
The National Institute of Mental Health (NIMH), part of the National Institutes of Health, is funding five new research projects that will shed light on antidepressant medications, notably selective serotonin reuptake inhibitors (SSRIs), and their association with suicidal thoughts and actions.
- Odds of Beating Depression Diminish as Additional Treatment Strategies are Needed
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November 1, 2006
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Science Update
An overall assessment of the nation's largest real-world study of treatment-resistant depression suggests that a patient with persistent depression can get well after trying several treatment strategies, but his or her odds of beating the depression diminish as additional treatment strategies are needed.
- Antipsychotic Medications Used to Treat Alzheimer’s Patients Found Lacking
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October 11, 2006
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Press Release
Commonly prescribed antipsychotic medications used to treat Alzheimer’s patients with delusions, aggression, hallucinations, and other similar symptoms can benefit some patients, but they appear to be no more effective than a placebo when adverse side effects are considered, according to the first phase of a large-scale clinical trial funded by NIMH.
