Clinical Trials
Prevention of Mental Disorders
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Prevention of Relapse & Recurrence of Bipolar Depression.
Interventional study. The purpose of this study is to determine whether the long-term use of combined antidepressant plus mood stabilizer therapy is superior to mood stabilizer therapy alone in preventing the relapse and recurrence of bipolar depression. Ages 18 and over. Locations in Chicago, IL; Philadelphia, PA.
- Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study).
Interventional study. This study will test an intervention that aims to prevent postpartum depression by providing new mothers with information on and resources for dealing with the disorder. Ages 18 and over. Location in New York, NY.
- Early Family-Focused Treatment for Youth at Risk of Bipolar Disorder.
Interventional study. This study will test a family-based therapy aimed at preventing or reducing the symptoms of bipolar disorder in at-risk children. Ages 9-17. Locations in Stanford, CA; Boulder, CO.
- Preventing Depression in the Children of Depressed African American Mothers.
Interventional study. This study will test a program for preventing depression from developing in the children of depressed African American mothers. Ages 18 and over. Location in Philadelphia, PA.
- Testing the Effectiveness of Adolescent Depression Prevention Programs (The OregonBlues Study).
Interventional study. This study will test the effectiveness of two programs for preventing depression in adolescents. Ages 13-19. Location in Eugene, OR.
- Examining the Effectiveness of an Early Psychological Intervention to Prevent Post-Traumatic Stress Disorder.
Interventional study. This study will examine the use of prolonged exposure therapy on people who have recently experienced a trauma to prevent them from developing post-traumatic stress disorder. Ages 18-65. Location in Atlanta, GA.
- Testing an HIV Prevention Intervention for Psychiatric Patients in Brazil.
Interventional study. This study will test the effectiveness of a program aimed at reducing behaviors that increase HIV risk among people with severe mental illnesses. Ages 18-80. Location in Rio de Janeiro, Brazil.
- Effectiveness of a Family-Based Treatment for Preventing Anxiety Disorders in At-Risk Children.
Interventional study. This study will test the effectiveness of a family-based behavioral program for preventing anxiety disorders in at-risk children. Ages 7-12. Location in Baltimore, MD.
- Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight.
Interventional study. This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight. Ages 20-60. Location in St. Louis, MO.
- Effectiveness of a Web-Based Prevention Program for Postpartum Depression.
Interventional study. This study will evaluate the effectiveness of a Web-based program in preventing postpartum depression. Ages 18-60. Location in San Francisco, CA.
- Effectiveness of a Parent Training Program for Parents of Children Adopted Internationally.
Interventional study. This study will test the effectiveness of a parent training program aimed at helping children who are adopted internationally to develop secure, organized attachments to their parents. Ages 12 months-30 months. Location in Newark, DE.
- HIV Prevention and Trauma Treatment in Men Who Have Sex With Men and Who Have a History of Sexual Abuse.
Interventional study. This study will develop a therapy for men who have sex with men who also have a history of childhood sexual abuse to reduce behaviors that put them at a high risk of HIV infection. Ages 18 and over. Location in Boston, MA.
- Customized Medication Adherence Enhancement for Treating Adults With Bipolar Disorder.
Interventional study. In this study, patients with bipolar disorder who do not take their medications as prescribed will receive specialized education and therapy treatment to determine whether the specialized treatment is effective in helping patients to take their medications consistently. Ages 18 and over. Location in Cleveland, OH.
- A School-Based HIV/STD Prevention Program to Reduce Risky Sexual Behaviors Among Adolescents in Liberia.
Interventional study. This study will evaluate the effectiveness of a school-based HIV/sexually transmitted disease prevention program in reducing sexual risk behaviors of youth attending school in Liberia. Ages 13-15. Location in Monrovia, Liberia.
- Effectiveness of a Family-Based Intervention for Adolescent Suicide Attempters (The SAFETY Study).
Interventional study. This study will evaluate the effectiveness of an individually tailored suicide prevention treatment program called SAFETY in reducing suicide and suicide attempts in adolescents. Ages 12-19. Location in Los Angeles, CA.
- Effectiveness of Community-Level Behavioral and Biomedical Interventions for Reducing HIV/STIs in Men in Peru.
Interventional study. This study will evaluate the effectiveness of community-level behavioral and biomedical interventions, each alone and combined, in reducing sexual risk behavior and HIV/sexually transmitted infections in Peruvian men who have sex with men. Ages 18-45. Location in Lima, Peru.
- Effectiveness of Neuroadaptive Cognitive Training in Adolescents at Risk for Psychosis.
Interventional study. This study will evaluate the effectiveness of intensive computerized cognitive training in preventing the onset of psychotic disorder and improving adaptive functioning in adolescents at high risk of schizophrenia. Ages 14-25. Locations in San Francisco, CA; Davis, CA.
- Providing Voluntary HIV Counseling and Testing Plus Linkage to Care in Uganda.
Interventional study. This study will compare the effectiveness of brief versus detailed HIV counseling sessions, paired with referrals to either HIV-specific medical care or usual care, in reducing HIV risk behavior and in increasing treatment adherence in Uganda. Ages 18 and over. Location in Kampala, Uganda.
- Effectiveness of HIV/Sexually Transmitted Infection Training for Physicians in China.
Interventional study. This study will evaluate the effectiveness of a physician training program, the Ai Shi Zi program, in improving HIV/sexually transmitted infection diagnosis, treatment, and management by Chinese physicians and in reducing the number of subsequent infections in their patients. Ages 18-45. Location in Hefei, China.
- Effectiveness of Emotion-Focused Cognitive Behavioral Therapy for Treating Adolescents With Emotional Disorders.
Interventional study. This study will evaluate the effectiveness of an emotion-focused cognitive behavioral treatment program for adolescents with anxiety or unipolar depressive disorders. Ages 12-17. Location in Miami, FL.
- Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women.
Interventional study. This study will evaluate the effectiveness of CenteringPregnancy Plus, a group prenatal care treatment program with an HIV/sexually transmitted disease prevention component, in reducing health risk behaviors in pregnant teenagers seeking services at Community Health Centers in the New York metropolitan area. Ages 14-21. Locations in New Haven, CT; Cheshire, CT; New York, NY.
- A Relapse Prevention Program for Reducing Relapse and Fear of Food in People With Anorexia Nervosa.
Interventional study. This study will compare the effectiveness of two types of psychotherapy, a relapse prevention program and cognitive behavioral therapy, in reducing relapse and fear of eating situations in people with anorexia nervosa. Ages 16-45. Location in New York, NY.
- Detecting Risk of Suicide in a Pediatric Emergency Department.
Evaluation study. Objective: The ultimate goal of this project is to enhance the capacity of non-mental health clinicians working in an Emergency Departments (ED) to recognize and initiate further evaluation of children and adolescents at risk for suicide. Ages 10-21. Locations in Washington, DC; Boston, MA; Columbus, OH.
- Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse.
Interventional study. This study will compare the effectiveness of fluoxetine alone with the effectiveness of fluoxetine with cognitive behavioral therapy in increasing recovery and preventing relapse in youth with major depressive disorder. Ages 8-17. Location in Dallas, TX.
- Interpersonal Treatment Program to Prevent Depression and Post-Traumatic Stress Disorder in Low-Income Pregnant Women With Partner Abuse.
Interventional study. This study will evaluate the effectiveness of an interpersonally oriented treatment program called Reach Out for a Safe Environment in preventing depression and post-traumatic stress disorder in low-income pregnant women who have experienced recent partner abuse. Ages 18-40. Location in Providence, RI.
- Depression Prevention for Pregnant Women on Public Assistance.
Interventional study. This study will evaluate the effectiveness of an interpersonal therapy treatment called the Postpartum Prevention Program in preventing the development of postpartum depression in pregnant women who are financially disadvantaged. Ages 18-40. Locations in Providence, RI; Woonsocket, RI; Pawtucket, RI.
- Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.
- Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment.
Interventional study. This study will evaluate the effectiveness of escitalopram to prevent depression in head and neck cancer patients receiving treatment. Ages 19 and over. Location in Omaha, NE.
- Follow-up Evaluation of Home Nurse Visitation Program for Socially Disadvantaged Women and Their Children.
Interventional study. This study will evaluate the long-term effects of a prenatal and early childhood home nurse visitation program for socially disadvantaged women and their children. Location in Elmira, NY.
- Parent Training to Promote Early Identification and Treatment of Childhood Behavioral Disorders.
Interventional study. This study will evaluate the effectiveness of a parent training program in improving parenting skills and reducing behavioral symptoms in young children who are at risk for developing childhood behavior disorders. Ages 22 months-38 months. Locations in Leominster, MA; Dorchester, MA; Westwood, MA; Woburn, MA; Westford, MA; Chelsea, MA.
- Evaluating the Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment.
Interventional study. This study will determine the effectiveness of an antidepressant in preventing or reducing depressive symptoms in people with melanoma who are receiving Interleukin-2 (IL-2) treatment. Ages 18-75. Location in Atlanta, GA.
- STD Risk Reduction for Heterosexual Methamphetamine Users.
Interventional study. This study will evaluate the effectiveness of a sexual risk reduction intervention in reducing sexual risk behavior in HIV uninfected, heterosexual people who use methamphetamine. Ages 18 and over. Location in San Diego, CA.
- Promoting Infant Mental Health in Foster Care.
Interventional study. This study will evaluate the effectiveness of the Promoting First Relationships (PFR) program versus an Early Education Support (EES) program in promoting infant well-being, preventing emotional and behavioral problems, countering developmental delay, and reducing placement instability in young foster care children. Ages 10 months-24 months. Location in Seattle, WA.
- Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
- Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy.
Interventional study. This study is designed to find out whether taking antipsychotic medication once every two weeks by injection compared to taking daily oral medication will help people with schizophrenia maintain better control of their symptoms. Ages 18-65. Locations in Los Angeles, CA; Augusta, GA; Iowa City, IA; Boston, MA; Fall River, MA; Omaha, NE; Albuquerque, NM; Glen Oaks, NY.
- Prevention of Depression in Spouses of People With Cognitive Impairment.
Interventional study. This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia. Ages 18 and over. Location in Pittsburgh, PA.
- Specialized Cognitive-Behavioral Counseling Intervention to Reduce HIV Transmission Risk Behavior in HIV-Infected Men.
Interventional study. This study will evaluate the effectiveness of a specialized cognitive-behavioral counseling intervention in reducing sexual risk behaviors in men who are HIV-infected and report having unprotected sex with male partners who are either not HIV-infected or do not know if they are HIV-infected. Ages 18 and over. Location in San Francisco, CA.
- Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand.
Interventional study. This study will evaluate the effectiveness of a combination of clinic- and community-based voluntary counseling and testing programs in preventing HIV in African and Thai communities. Ages 16 and over. Locations in Soweto, Johannesburg, South Africa; Pietermaritzburg, South Africa; Dar es Salaam, Tanzania; Chiang Mai, Thailand; Harare, Zimbabwe.
- Family Cognitive Behavioral Therapy for Preventing Depression in Children.
Interventional study. This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression. Ages 10 and over. Location in Nashville, TN.
- Effect of Family-Based Prevention on Children of Depressed Parents.
Interventional study. This study will test the Protecting Families Program, a 10-week prevention program for depressed parents and their pre-teenage children, by comparing the effectiveness of the program versus parent training alone. Ages 9 and over. Location in Philadelphia, PA.
- A Clinic-Based Prevention Program for Families of Depressed Mothers.
Interventional study. This study will assess the effectiveness of the "Keeping Families Strong" program (KFS) in avoiding or delaying the onset of psychiatric disorders among children with depressed mothers. Ages 8 and over. Location in Baltimore, MD.
- Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder.
Interventional study. This study will assess the relapse-prevention rate of escitalopram (Lexapro) in the treatment of body dysmorphic disorder. Ages 18 and over. Locations in Boston, MA; Providence, RI.
- Preventing Anxiety Disorders in Youth.
Interventional study. This study will determine the effectiveness of a cognitive behavioral therapy program in preventing anxiety disorders in at-risk children. Ages 8-12. Location in Baltimore, MD.
- Clinical Trial of Estrogen for Postpartum Depression.
Interventional study. This study evaluates the efficacy of estrogen treatment in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.
